Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum

被引：44
|
作者：
Zou, J
Jin, DZ
Chen, WL
Wang, J
Liu, QF
Zhu, XZ [1 ]
Zhao, WM
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Pharmacol, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Dept Nat Prod, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 10期
关键词：
D O I：
10.1021/np0502342
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC50 = 2.99 and 1.80 mu M) in vitro.
引用
收藏
页码：1514 / 1518
页数：5
相关论文
共 50 条
  • [1] Selective cyclooxygenase-2 inhibitors
    Auleley, GR
    Deligne, J
    Hantson, C
    Blum-Boisgard, C
    PRESSE MEDICALE, 2005, 34 (10): : 703 - 710
  • [2] Selective cyclooxygenase-2 inhibitors
    Hettich, M
    INTERNIST, 1997, 38 (10): : 1007 - 1007
  • [3] Selective cyclooxygenase-2 inhibitors
    Black, WC
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 39, 2004, 39 : 125 - 138
  • [4] Selective cyclooxygenase-2 inhibitors
    Prasit, P
    Riendeau, D
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 32, 1997, 32 : 211 - 220
  • [5] Selective cyclooxygenase-2 inhibitors
    Golden, BD
    Abramson, SB
    RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 1999, 25 (02) : 359 - +
  • [6] Selective inhibitors of cyclooxygenase-2
    Talley, JJ
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (01) : 55 - 62
  • [7] Cyclooxygenase-2 selective inhibitors
    Cannon, GW
    DRUGS OF TODAY, 1999, 35 (07) : 487 - 496
  • [8] Selective cyclooxygenase-2 inhibitors
    Lloyd, AW
    DRUG DISCOVERY TODAY, 1999, 4 (07) : 334 - 335
  • [9] RXRα transcriptional inhibitors from the stems of Calophyllum membranaceum
    Ming, Meng
    Zhang, Xue
    Chen, Hai-Feng
    Zhu, Ling-Juan
    Zeng, De-Quan
    Yang, Jian
    Wu, Guang-Xun
    Wu, Yu-Zhuo
    Yao, Xin-Sheng
    FITOTERAPIA, 2016, 108 : 66 - 72
  • [10] The coxibs, selective inhibitors of cyclooxygenase-2
    Killen, JP
    NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (23): : 1708 - 1708
12345