Synthesis of regioisomeric N- and O-alkylated 3-polyfluoroalkyl-1,2-dihydroquinoxalin-2-ones

被引：2

作者：

Ivanova, A. E. ^{[1
]}

Khudina, O. G. ^{[1
]}

Burgart, Ya V. ^{[1
]}

Saloutin, V. I. ^{[1
]}

机构：

[1] Russian Acad Sci, Ural Branch, I Ya Postovsky Inst Organ Synth, Ekaterinburg 620041, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2011年 / 60卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

analogs of acyclic nucleosides; 3-polyfluoroalkylquinoxalin-2-ones; alkylation; regioisomers; deacylation; ANTITUMOR AGENT; ANALOGS; 9-(2-HYDROXYETHOXYMETHYL)GUANINE;

D O I：

10.1007/s11172-011-0147-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3-Polyfluoroalkyl-1,2-dihydroquinoxalin-2-ones react with 4-bromobutyl acetate to furnish 1-(4-acetoxybutyl)quinoxalin-2-ones and 2-(4-acetoxybutoxy)quinoxalines in the ratio 2: 1. Deacylation of these compounds under acidic conditions gives the corresponding 1-(4-hydroxybutyl)- and 2-(4-hydroxybutoxy)-substituted quinoxalines. The structures of compounds synthesized were established by X-ray crystallography, IR spectroscopy, H-1 and F-19 NMR spectroscopy, GLC-MS.

引用

页码：937 / 941

页数：5

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