Multisession anodal transcranial direct current stimulation induces motor cortex plasticity enhancement and motor learning generalization in an aging population

被引：19
|
作者：
Dumel, Gaelle [1 ,2 ]
Bourassa, Marie-Eve [1 ,2 ]
Charlebois-Plante, Camille [1 ]
Desjardins, Martine [1 ,2 ]
Doyon, Julien [4 ]
Saint-Amour, Dave [2 ]
De Beaumont, Louis [1 ,3 ]
机构：
[1] Hop Sacre Coeur, Ctr Rech, 5400 Blvd Gouin Ouest, Montreal, PQ H4J 1C5, Canada
[2] Univ Quebec, Dept Psychol, 100 Rue Sherbrooke Ouest, Montreal, PQ H2X 3P2, Canada
[3] Univ Montreal, Dept Chirurg, 2900 Blvd Edouard Montpetit, Montreal, PQ H3T 1J4, Canada
[4] Inst Geriatrie Montreal, Ctr Rech, Unite Neuroimagerie Fonct, 4545 Chemin Queen Mary, Montreal, PQ H3W 1W4, Canada
来源：
CLINICAL NEUROPHYSIOLOGY | 2018年 / 129卷 / 02期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Brain plasticity; Geriatrics; Motor cortex; Motor learning generalization; Noninvasive brain stimulation; Cortical inhibition; GABA(B) RECEPTOR ANTAGONIST; MAGNETIC STIMULATION; SKILL ACQUISITION; BRAIN-STIMULATION; WORKING-MEMORY; EXCITABILITY; INHIBITION; POLARIZATION; FACILITATION; PERFORMANCE;
D O I：
10.1016/j.clinph.2017.10.041
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: The present aging study investigated the impact of a multisession anodal-tDCS protocol applied over the primary motor cortex (M1) during motor sequence learning on generalization of motor learning and plasticity-dependent measures of cortical excitability. Methods: A total of 32 cognitively-intact aging participants performed five consecutive daily 20-min sessions of the serial-reaction time task (SRTT) concomitant with either anodal (n = 16) or sham (n = 16) tDCS over M1. Before and after the intervention, all participants performed the Purdue Pegboard Test (PPT) and Transcranial Magnetic Stimulation (TMS) measures of cortical excitability were collected. Results: Relative to sham, participants assigned to the anodal-tDCS intervention revealed significantly greater performance gains on both the trained SRTT and the untrained PPT as well as a greater disinhibition of long-interval cortical inhibition (LICI). Generalization effects of anodal-tDCS significantly correlated with LICI disinhibition. Conclusion: Anodal-tDCS facilitates motor learning generalisation in an aging population through intracortical disinhibition effects. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：494 / 502
页数：9
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