Visible Light Mediated, Catalyst Free, One-Pot Convenient Synthesis of Dihydropyridines

被引：3
|
作者：
Di, Jia-Qi [1 ]
Chen, Meng-Nan [1 ]
Zhao, Ai-Dong [2 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Hebei Key Lab Organ Funct Mol, Shijiazhuang 050024, Hebei, Peoples R China
[2] Hebei Normal Univ, Anal & Testing Ctr, Shijiazhuang 050024, Hebei, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Catalyst-free; dihydropyridine; green chemistry; multi-component reaction; visible light; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; 1,4-DIHYDROPYRIDINES; DERIVATIVES; SOLVENT;
D O I：
10.2174/1570178618666210125162342
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient and green protocol has been developed for the synthesis of polysubstituted dihydropyridines via one-pot, four-component reaction of aldehydes, arylamines, dialkyl acetylenedicarboxylate, and malononitrile. The reaction was proceeded at room temperature in the absence of catalyst in aqueous ethyl lactate under visible light irradiation. The main advantages of the present approach are mild reaction conditions, high yield, no column chromatography, clean reaction profile, environmentally friendly and sustainability from the economic point of view.
引用
收藏
页码：276 / 282
页数：7
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