Nanoprobes for in vitro diagnostics of cancer and infectious diseases

被引：115

作者：

Chi, Xiaoqin ^{[1
,2
,3
]}

Huang, Dengtong ^{[1
,2
]}

Zhao, Zhenghuan ^{[1
,2
]}

Zhou, Zijian ^{[1
,2
]}

Yin, Zhenyu ^{[3
]}

Gao, Jinhao ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Zhongshan Hosp, Xiamen 361004, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Nanoprobes; In vitro diagnostics; Molecular identification; Protein detection; Cancer; Infectious diseases; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; RESONANCE ENERGY-TRANSFER; PROTEIN-PROTEIN INTERACTIONS; SEMICONDUCTOR QUANTUM DOTS; ENHANCED RAMAN-SCATTERING; CARBON NANOTUBES; LIVE CELLS; SINGLE-MOLECULE; ELECTRICAL DETECTION; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.biomaterials.2011.09.032

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The successful and explosive development of nanotechnology is significantly impacting the fields of biology and medicine. Among the spectacular developments of nanobiotechnology, interest has grown in the use of nanomaterials as nanoprobes for bioanalysis and diagnosis. Herein, we review state-of-the-art nanomaterial-based probes and discuss their applications in in vitro diagnostics (IVD) and challenges in bringing these fields together. Major classes of nanoprobes include quantum dots (QDs), plasmonic nanoparticles, magnetic nanoparticles, nanotubes, nanowires, and multifunctional nanomaterials. With the advantages of high volume/surface ratio, surface tailorability, multifunctionality, and intrinsic properties, nanoprobes have tremendous applications in the areas of biomarker discovery, diagnostics of infectious diseases, and cancer detection. The distinguishing features of nanoprobes for in vitro use, such as harmlessness, ultrasensitivity, multiplicity, and point-of-care use, will bring a bright future of nanodiagnosis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：189 / 206

页数：18

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