Traditional Chinese medicines and Alzheimer's disease

被引：97

作者：

Wu, Tzong-Yuan ^{[2
,3
,4
]}

Chen, Chip-Ping ^{[1
,5
,6
,7
,8
,9
]}

Jinn, Tzyy-Rong ^{[1
]}

机构：

[1] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 40402, Taiwan

[2] Chung Yuan Christian Univ, Dept Biosci Technol, Chungli, Taiwan

[3] Chung Yuan Christian Univ, Ctr Nanotechnol, Chungli, Taiwan

[4] Chung Yuan Christian Univ, R&D Ctr Membrane Technol, Chungli, Taiwan

[5] Mackay Mem Hosp, Dept Obstet & Gynecol, Taipei, Taiwan

[6] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan

[7] Asia Univ, Dept Biotechnol, Taichung, Taiwan

[8] Natl Yang Ming Univ, Inst Clin & Community Hlth Nursing, Taipei 112, Taiwan

[9] Natl Yang Ming Univ, Dept Obstet & Gynecol, Sch Med, Taipei 112, Taiwan

来源：

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY | 2011年 / 50卷 / 02期

关键词：

Acetylcholinesterase; Alzheimer's disease; Cognitive impairment; Dementia; Neuroprotection; Traditional Chinese medicine; NATURAL CHOLINESTERASE INHIBITOR; GINKGO-BILOBA EXTRACT; HUPERZINE-A; IN-VITRO; NEUROTROPHIC FACTORS; NICOTINIC RECEPTORS; SALVIA-OFFICINALIS; CORTICAL-NEURONS; BRAIN ISCHEMIA; PC12; CELLS;

D O I：

10.1016/j.tjog.2011.04.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Traditional Chinese medicines have been widely investigated for the treatment of Alzheimer's disease (AD) because none of the current therapies-either the cholinesterase inhibitors or antagonist of N-methyl-D-aspartate receptors-has profound effects on halting the progression of AD. In recent years, scientists have isolated many active compounds from herbs, which can alleviate dementia and neurodegenerative syndrome with fewer side effects than conventional drugs and, thus, are regarded as promising drug candidates for AD therapy. In this review, we summarize the latest research progress on six herbs for AD therapy-Huperzia serrata, Amaryllidaceae family, Ginkgo biloba, Uncaria rhynchophylla, Polygala tenuifolia, and Salvia officinalis-and focus on the analysis of their active components and possible mechanisms of pharmacological actions on AD. Copyright (C) 2011, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.

引用

页码：131 / 135

页数：5

共 53 条

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