REVEALing the effect of CETP inhibition in cardiovascular disease

被引：40

作者：

Holmes, Michael V. ^{[1
,2
,3
,4
,5
]}

Smith, George Davey ^{[6
,7
,8
]}

机构：

[1] Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford OX3 7LF, England

[2] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Roosevelt Dr, Oxford OX3 7LF, England

[3] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Roosevelt Dr, Oxford OX3 7LF, England

[4] Oxford Univ Hosp, Oxford Biomed Res Ctr, Natl Inst Hlth Res, Old Rd, Oxford OX3 7LE, England

[5] Univ Bristol, Med Res Council Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England

[6] MRC, Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England

[7] Natl Inst Hlth Res, Bristol Biomed Res Ctr, Oakfield House, Bristol BS8 2BN, Avon, England

[8] Univ Bristol, Sch Social & Community Med, Barley House, Bristol BS8 2BN, Avon, England

来源：

NATURE REVIEWS CARDIOLOGY | 2017年 / 14卷 / 11期

基金：

英国医学研究理事会;

关键词：

CORONARY-ARTERY-DISEASE; HIGH-RISK;

D O I：

10.1038/nrcardio.2017.156

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Initial randomized trials of cholesteryl ester transfer protein (CETP) inhibitors were terminated early owing to adverse effects or futility. The REVEAL trial now shows the benefit of CETP inhibition in coronary heart disease. Despite raising HDL-cholesterol levels, the cardiovascular effect of CETP inhibitors is probably due to lowering of non-HDL-cholesterol levels.

引用

页码：635 / 636

页数：2

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