Bacteriophage therapy: recent developments and applications of a renaissant weapon

被引:28
作者
Fathima, Bibi [1 ]
Archer, Ann Catherine [1 ]
机构
[1] JSS Acad Higher Educ & Res, Fac Life Sci, Dept Microbiol, Mysuru 570015, Karnataka, India
关键词
Bacteriophage; Modern approaches; Phage therapy applications and limitations; GENETICALLY-ENGINEERED PHAGE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; HOST-RANGE; INFECTIONS; VOLUNTEERS; BIOFILMS; COCKTAIL; BLIGHT; COMBAT;
D O I
10.1016/j.resmic.2021.103863
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Antimicrobial resistance is a global health problem and one of the leading concerns in healthcare sector. Bacteriophages are antibacterial agents ubiquitous in nature. With increase in antibiotic resistance, use of bacteriophages as therapeutics has become resurgent in recent times. This review focuses on the recent developments in phage therapy and its applications with respect to human infections, animal, food and environment. Moreover, use of phage proteins, bioengineered bacteriophages, and phage derived vaccines is also highlighted. Additionally, the limitations and challenges with regard to implementation of phage therapy, host safety and immune responses are also reviewed in this article. (c) 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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页数:8
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