Hydrophobin-enhanced stability, dispersions and release of curcumin nanoparticles in water

被引：10

作者：

Niu, Baolong ^{[1
,2
]}

Li, Meilin ^{[2
]}

Jia, Jianhong ^{[2
]}

Zhang, Ce ^{[1
]}

Fan, Yan-Ying ^{[1
]}

Li, Wenfeng ^{[2
]}

机构：

[1] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China

[2] Taiyuan Univ Technol, Coll Mat Sci & Engn, Taiyuan, Peoples R China

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2020年 / 31卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Hydrophobin; self-assembly; amphipathic; curcumin; CLASS-I HYDROPHOBIN; SOLUBILITY; FUNCTIONALIZATION; EXFOLIATION; PROTEINS; GRAPHENE; HFBI;

D O I：

10.1080/09205063.2020.1775761

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Most chemotherapeutic drugs commonly suffer from low aqueous solubility that can potentially limit drugs absorption. Drug nano-merization is an advanced approach to overcoming their poor water-solubility. In this study, class I hydrophobin recombinant HGFI (rHGFI)-based curcumin (Cur) nanoparticles (rHGFI-Cur) were prepared by freeze-drying method. The rHGFI-Cur nanocomposites were characterized by contact angle, transmission electron microscopy, fluorescence microscopy and dynamic light scattering. The results showed that rHGFI could lead to the wettability conversion and stability improved of Cur in water. X-ray photoelectron spectroscopy and Fourier transform infrared suggested that rHGFI could non-covalently bind to Cur to render them hydrophilic through hydrophobic forces. Additionally, drug release and cytotoxicity assays illustrated that rHGFI-Cur nanoparticles could facilitate Cur release and exhibited higher cytotoxicity than free Cur for human esophageal cancer cells TE-1. Thus, it suggested that rHGFI has a great potential application for hydrophobic drug delivery without toxicity. [GRAPHICS] .

引用

页码：1793 / 1805

页数：13

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