Gallstone formation - Local factors

被引：39

作者：

Ko, CW

Lee, SP

机构：

[1] Vet Affairs Puget Sound Hlth Care Syst, Dept Med 111 GI A, Div Gastroenterol, Seattle, WA 98108 USA

[2] Univ Washington, Seattle, WA 98195 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 01期

关键词：

D O I：

10.1016/S0889-8553(05)70045-5

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Supersaturation of bile is a necessary prerequisite to gallstone formation. However, patients who have undergone a cholecystectomy do not form gallstones. This indicates a role of local factors in gallstone formation. Gallbladder stasis, mucin secretion, the presence of pronucleating and antinucleating biliary proteins, and some medications have been shown to alter gallstone formation. New data has also caused the role of bacterial infection in gallstone pathogenesis to be re-examined. in addition, genetic factors have recently been identified which may predispose to gallstone formation by altering the secretion of hepatic bile.

引用

页码：99 / +

页数：19

共 130 条

[1] IDENTIFICATION OF HUMAN BILIARY ALPHA(1)-ACID GLYCOPROTEIN AS A CHOLESTEROL CRYSTALLIZATION PROMOTER [J].