Cell-free conversion of 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate into β-carotene in higher plants and its inhibition by fosmidomycin

被引：42
作者：
Fellermeier, M
Kis, K
Sagner, S
Maier, U
Bacher, A
Zenk, MH
机构：
[1] Univ Munich, Lehrstuhl Pharmazeut Biol, D-80333 Munich, Germany
[2] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Munich, Germany
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期
关键词：
1-deoxy-D-xylulose; 5-phosphate; 2-C-methyl-D-erythritol; 4-phosphate; isopentenyl diphosphate; terpenoid biosynthesis;
D O I：
10.1016/S0040-4039(99)00361-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The presence of the deoxyxylulose pathway in chromo- and chloroplasts of various higher plants was demonstrated by the conversion of labelled 1-deoxy-D-xylulose 5-phosphate into beta-carotene and geranylgeraniol, in the presence of ATP. The antibiotic fosmidomycin inhibited the formation of terpenoids from 1-deoxy-D-xylulose 5-phosphate, whereas it did not affect the conversion of 2-C-methyl-D-erythritol 4-phosphate or isopentenyl diphosphate into terpenoids. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2743 / 2746
页数：4
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