Novel Taxa-4(20),12-diene and 2(3→20)Abeotaxane from Needles of Taxus canadensis

被引：4

作者：

Ni, Zhi-Yu ^{[2
]}

Wu, Yi-Bing ^{[1
]}

Zhang, Man-Li ^{[1
]}

Wang, Yu-Fang ^{[1
]}

Dong, Mei ^{[2
]}

Sauriol, Francoise ^{[3
]}

Huo, Chang-Hong ^{[1
]}

Shi, Qing-Wen ^{[1
]}

Gu, Yu-Cheng ^{[4
]}

Kiyota, Hiromasa ^{[5
]}

Cong, Bin ^{[2
]}

机构：

[1] Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei Prov, Peoples R China

[2] Hebei Med Univ, Coll Basic Med, Shijiazhuang 050017, Hebei Prov, Peoples R China

[3] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada

[4] Jealotts Hill Int Res Ctr, Syngenta RG42 6EY, Berks, England

[5] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2011年 / 75卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Taxus canadensis; needle; taxane; taxa-4(20); 12-diene; isolation; TAXANES; TAXOIDS; ANALOGS;

D O I：

10.1271/bbb.110223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel 6/8/6-membered taxane with a rare C-12(13)-double bond and rare 2(3 -> 20)abeotaxane were isolated from the needles of Taxus canadensis. Their structures were characterized as 7 beta,9 alpha,10 beta-triacetoxy-taxa-4(20),12-diene-2 alpha,5 alpha,11 beta-triol (1) and 2 alpha,7 beta,10 beta-triacetoxy-5 alpha-hydroxy-2 (3 -> 20)abeotaxa-4(20),11-diene-9,13-dione (2) on the basis of 1D and 2D spectroscopic data. 1 is the first example of a natural taxane without substitution at both C-13 and C-14.

引用

页码：1698 / 1701

页数：4

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