Association of Choroidal Interleukin-17-Producing T Lymphocytes and Macrophages with Geographic Atrophy

被引：12

作者：

Camelo, Serge ^{[1
]}

Lavelette, Sophie ^{[2
]}

Guillonneau, Xavier ^{[2
]}

Raoul, William ^{[3
]}

Sennlaub, Florian ^{[2
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, AP HP, Unite Rech Clin Lariboisiere St Louis, Paris, France

[2] Univ Paris 06, Sorbonne Univ, INSERM, Inst Vis,CNRS, Paris, France

[3] Univ Tours, CNRS, GICC UMR 7292, Tours, France

来源：

OPHTHALMOLOGICA | 2016年 / 236卷 / 01期

关键词：

Interleukin-17; Lymphocytes; CD3; Choroid; Geographic atrophy; Age-related macular degeneration; MACULAR DEGENERATION; AGE; CELLS; PATHOGENESIS; INFLAMMATION; POLYMORPHISM; DISEASE; LESIONS; T(H)17;

D O I：

10.1159/000446587

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA). Methods: In this short report, we analyzed IL-17, CD3, and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age matched control donors. Results/Conclusion: We showed that IL-17(+) cells are found near areas of retinal pigmented epithelium atrophy in the eyes of GA patients. IL-17+ cells mainly localized to CD3(+) cells, which identifies T lymphocytes, as well as IBA-1(+) cells, which identifies mononuclear phagocytes. Therefore, IL-17 could be involved in the pathological mechanisms that contribute to the degeneration observed in GA. (C) 2016 S. Karger AG, Basel

引用

页码：53 / 58

页数：6

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