Discovering cellular protein-protein interactions: Technological strategies and opportunities

被引：58

作者：

Titeca, Kevin ^{[1
,2
]}

Lemmens, Irma ^{[1
,2
]}

Tavernier, Jan ^{[1
,2
]}

Eyckerman, Sven ^{[1
,2
]}

机构：

[1] VIB, VIB Ctr Med Biotechnol, Ghent, Belgium

[2] Univ Ghent, Dept Biochem, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium

来源：

MASS SPECTROMETRY REVIEWS | 2019年 / 38卷 / 01期

基金：

欧洲研究理事会;

关键词：

binary interactomics; co-complex interactomics; interactomics technologies; protein-protein interactions; TANDEM AFFINITY PURIFICATION; RESONANCE ENERGY-TRANSFER; CHEMICAL CROSS-LINKING; LUCIFERASE COMPLEMENTATION ASSAY; QUANTITATIVE PROTEOMIC ANALYSIS; ENZYME-MEDIATED ACTIVATION; MEMBRANE 2-HYBRID ASSAY; MASS-SPECTROMETRY DATA; LIVING CELLS; LABEL-FREE;

D O I：

10.1002/mas.21574

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The analysis of protein interaction networks is one of the key challenges in the study of biology. It connects genotypes to phenotypes, and disruption often leads to diseases. Hence, many technologies have been developed to study protein-protein interactions (PPIs) in a cellular context. The expansion of the PPI technology toolbox however complicates the selection of optimal approaches for diverse biological questions. This review gives an overview of the binary and co-complex technologies, with the former evaluating the interaction of two co-expressed genetically tagged proteins, and the latter only needing the expression of a single tagged protein or no tagged proteins at all. Mass spectrometry is crucial for some binary and all co-complex technologies. After the detailed description of the different technologies, the review compares their unique specifications, advantages, disadvantages, and applicability, while highlighting opportunities for further advancements.

引用

页码：79 / 111

页数：33

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