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Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
被引:207
作者:
Galli, Filippo
[1
]
Aguilera, Jesus Vera
[2
]
Palermo, Belinda
[3
,4
]
Markovic, Svetomir N.
[2
]
Nistico, Paola
[3
,4
]
Signore, Alberto
[1
]
机构:
[1] Sapienza Univ Rome, S Andrea Univ Hosp, Dept Med Surg Sci & Translat Med, Nucl Med Unit, Rome, Italy
[2] Mayo Clin, Dept Oncol, Rochester, MN USA
[3] Mayo Clin, Dept Immunol, Rochester, MN USA
[4] IRCCS Regina Elena Natl Canc Inst, Tumor Immunol & Immunotherapy Unit, Dept Res Adv Diagnost & Technol Innovat, Rome, Italy
关键词:
molecular imaging;
tumor microenvironment;
onco-immunology;
immunotherapy;
lymphocytes;
IN-VIVO TRACKING;
EPITHELIAL-MESENCHYMAL TRANSITION;
FIBROBLAST ACTIVATION PROTEIN;
NATURAL-KILLER-CELLS;
REGULATORY T-CELLS;
CANCER-IMMUNOTHERAPY;
DENDRITIC CELLS;
METASTATIC MELANOMA;
ANTITUMOR IMMUNITY;
SUPPRESSOR-CELLS;
D O I:
10.1186/s13046-020-01586-y
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor progression, metastatization and resistance to therapy. New immunotherapeutic approaches aim at restoring the natural balance and increase immune response against cancer by different mechanisms. The complexity of these interactions and the heterogeneity of immune cell subpopulations are a real challenge when trying to develop new immunotherapeutics and evaluate or predict their efficacy in vivo. To this purpose, molecular imaging can offer non-invasive diagnostic tools like radiopharmaceuticals, contrast agents or fluorescent dyes. These agents can be useful for preclinical and clinical purposes and can overcome [F-18]FDG limitations in discriminating between true-progression and pseudo-progression. This review provides a comprehensive overview of immune cells involved in microenvironment, available immunotherapies and imaging agents to highlight the importance of new therapeutic biomarkers and their in vivo evaluation to improve the management of cancer patients.
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页数:21
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