Plasmid-mediated extended-spectrum β-lactamase (CTX-M-3 like) from India and gene association with insertion sequence ISEcp1

被引：174

作者：

Karim, A

Poirel, L

Nagarajan, S

Nordmann, P

机构：

[1] Assistance Publ Hop Paris, Hop Bicetre, Fac Med Paris Sud, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Batra Hosp, Dept Microbiol, New Delhi 110062, India

[3] Med Res Ctr, New Delhi 110062, India

来源：

FEMS MICROBIOLOGY LETTERS | 2001年 / 201卷 / 02期

关键词：

beta-lactamase; CTX-M; India; insertion sequence;

D O I：

10.1016/S0378-1097(01)00276-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Six non-clonally related enterobacterial isolates producing a same extended-spectrum beta -lactamase CTX-M-15 were isolated in 1999 from patients hospitalized in a New Delhi hospital. CTX-M-15 differed from CTX-M-3 by an asparagine to glycine substitution in position ABL238. Its gene was located on large plasmids varying in size. In each case, a same insertion sequence ISEcp1 was identified upstream of the 5' end of bla(CTX-M-15). Typical -35 and -10 promoter sequences of Enterobacteriaceae were identified in the 3' end of ISEcp1. The location of ISEcp1 upstream of plasmid-mediated CTX-M-type beta -lactamase genes may contribute to their spread or/and their expression. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：237 / 241

页数：5

共 15 条

[1] Molecular characterization of the SHV-11 β-lactamase of Shigella dysenteriae [J].

Ahamed, J ;

Kundu, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) :2081-2083

[2] CLOSE AMINO-ACID-SEQUENCE RELATIONSHIP BETWEEN THE NEW PLASMID-MEDIATED EXTENDED-SPECTRUM BETA-LACTAMASE-BULLET-MEN-1 AND CHROMOSOMALLY ENCODED ENZYMES OF KLEBSIELLA-OXYTOCA [J].

BARTHELEMY, M ;

PEDUZZI, J ;

BERNARD, H ;

TANCREDE, C ;

LABIA, R .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1122 (01) :15-22

[3] Sequences of p-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases [J].

Bauernfeind, A ;

Stemplinger, I ;

Jungwirth, R ;

Ernst, S ;

Casellas, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (02) :509-513

[4] A novel CTX-M β-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil [J].

Bonnet, R ;

Sampaio, JLM ;

Labia, R ;

De Champs, C ;

Sirot, D ;

Chanal, C ;

Sirot, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1936-1942

[5] First isolation of a CTX-M-3-producing Enterobacter cloacae in France [J].

Doucet-Populaire, F ;

Ghnassia, JC ;

Bonnet, R ;

Sirot, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3239-3240

[6] Molecular epidemiology of the integron-located VEB-1 extended-spectrum β-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand [J].

Girlich, D ;

Poirel, L ;

Leelaporn, A ;

Karim, A ;

Tribuddharat, C ;

Fennewald, M ;

Nordmann, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (01) :175-182

[7]

Hansotia JB, 1997, INDIAN J MED RES, V105, P158

[8] An SHV-derived extended-spectrum β-lactamase in Pseudomonas aeruginosa [J].

Naas, T ;

Philippon, L ;

Poirel, L ;

Ronco, E ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (05) :1281-1284

[9]

NANDIVADA LS, 1989, FEMS MICROBIOL LETT, V57, P219

[10] PLASMID-MEDIATED BETA-LACTAM RESISTANCE IN PATHOGENIC GRAM-NEGATIVE BACTERIA ISOLATED IN SOUTH-INDIA [J].

NANDIVADA, LS ;

AMYES, SGB .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 (02) :279-290

← 1 2 →