Photonic crystal enhanced fluorescence using a quartz substrate to reduce limits of detection

被引：0
|
作者：
Pokhriyal, Anusha [1 ]
Lu, Meng [4 ]
Chaudhery, Vikram [3 ]
Huang, Cheng-Sheng [3 ]
Schulz, Stephen [4 ]
Cunningham, Brian T. [2 ,3 ]
机构：
[1] Univ Illinois, Dept Phys, 1110 W Green St, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Bio Engn, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA
[4] SRU Biosyst, Andover, MA 01810 USA
来源：
2011 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) | 2011年
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中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A Photonic Crystal surface fabricated upon a quartz substrate using nanoimprint lithography has been demonstrated with a signal enhancement factor as high as 7500x for the detection of LD-700 dye spin-coated upon the PC. The detection of spotted Alexa-647 labeled polypeptide on the PC exhibits a 330x SNR improvement. Using dose-response characterization of deposited fluorophore-tagged protein spots, the PCEF surface demonstrated a 140x lower limit of detection compared to a conventional glass substrate. (C)2010 Optical Society of America
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页数：2
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