Long-term efficacy and safety of firocoxib in the treatment of dogs with osteoarthritis

被引：31

作者：

Autefage, A. ^{[1
]}

Palissier, F. M. ^{[1
]}

Asimus, E. ^{[1
]}

Pepin-Richard, C. ^{[2
]}

机构：

[1] Ecole Natl Vet Toulouse, Unite Chirurg, Dept Sci Clin Anim Compagnie, F-31076 Toulouse 3, France

[2] Merial, F-69100 Villeurbanne, France

来源：

VETERINARY RECORD | 2011年 / 168卷 / 23期

关键词：

CYCLOOXYGENASE-2; INHIBITOR; CARPROFEN; NSAID; MANAGEMENT; TRIAL;

D O I：

10.1136/vr.d1456

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Thirty-nine client-owned dogs with osteoarthritis were treated with 5 mg/kg firocoxib administered orally, once a day for 52 weeks. Veterinary examinations were performed on approximately days 0, 15, 90, 180, 270 and 360. Twenty-five dogs completed the study. The withdrawal rate associated with gastrointestinal side effects was low (5.1 per cent of dogs). Based on the owners' assessment, 82 per cent of the dogs had improved at day 15, 84 per cent of the 32 remaining dogs had improved at day 90, and 96 per cent of the 25 dogs that completed the trial had improved at day 360. During this trial, 12 (48 per cent) of the 25 remaining dogs showed an improvement in their lameness from day 90 to day 360 (P < 0.05).

引用

页数：5

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