MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer

被引：0

作者：

Xhemo, Edlira ^{[1
]}

Fajac, Anne ^{[2
]}

Boire, Jean-Yves ^{[3
]}

Levy, Pierre P. ^{[4
,5
,6
]}

机构：

[1] Tenon Hosp, Dept Publ Hlth, Paris, France

[2] Tenon Hosp, Histol Dept, F-75020 Paris, France

[3] ERIM, Fac Med, F-63001 Clermont Ferrand 1, France

[4] Tenon Hosp, AP HP, Dept Publ Hlth, F-75970 Paris 20, France

[5] Univ Paris 06, Inserm UMR S 707, F-75012 Paris, France

[6] INSERM, UMR S707, F-75012 Paris, France

来源：

2007 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-16 | 2007年

关键词：

MDR1; ABCB1; polymorphism; visualization; data base; infoxel; generalized CaseView;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents the Generalized CaseView method applied to the study of polymorphisms of MDR1 (Multi Drug Resistant), a gene coding for a trans-membrane transporting protein. The data base contains Single nucleotide polymorphisms, their positions in cDNA, and the Area Under the Curve of drugs concentrations. The generalized CaseView method permits a compact visualization of these data. The main result is that pharmacokinetics of some anticancer drugs depends on the genotype.

引用

页码：4592 / +

页数：2

共 11 条

[1]

GLIGOROV J, 2007, 98 AM ASS CANC RES A

[2]

GLIGOROV J, 2006, 97 AM ASS CANC RES A

[3] Deciphering cellular states of innate tumor drug responses [J].