Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations

被引:44
作者
Chen-Plotkin, A. S. [1 ,2 ,3 ]
Yuan, W. [1 ,2 ]
Anderson, C. [3 ]
Wood, E. McCarty [1 ,2 ]
Hurtig, H. I. [3 ]
Clark, C. M. [1 ,2 ,3 ]
Miller, B. L. [4 ]
Lee, V. M. -Y. [1 ,2 ]
Trojanowski, J. Q. [1 ,2 ]
Grossman, M. [3 ]
Van Deerlin, V. M. [1 ,2 ]
机构
[1] Univ Penn, Sch Med, Ctr Neurodegenerat Dis Res, Inst Aging, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
关键词
D O I
10.1212/01.WNL.0000280574.17166.26
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Mutations in the LRRK2 gene are an important cause of familial and nonfamilial parkinsonism. Despite pleomorphic pathology, LRRK2 mutations are believed to manifest clinically as typical Parkinson disease (PD). However, most genetic screens have been limited to PD clinic populations. Objective: To clinically characterize LRRK2 mutations in cases recruited from a spectrum of neurodegenerative diseases. Methods: We screened for the common G2019S mutation and several additional previously reported LRRK2 mutations in 434 individuals. A total of 254 patients recruited from neurodegenerative disease clinics and 180 neurodegenerative disease autopsy cases from the University of Pennsylvania brain bank were evaluated. Results: Eight cases were found to harbor a LRRK2 mutation. Among patients with a mutation, two presented with cognitive deficits leading to clinical diagnoses of corticobasal syndrome and primary progressive aphasia. Conclusion: The clinical presentation of LRRK2-associated neurodegenerative disease may be more heterogeneous than previously assumed.
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收藏
页码:521 / 527
页数:7
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