TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

被引：51

作者：

Cox, David G. ^{[1
]}

Penney, Kathryn

Guo, Qun

Hankinson, Susan E.

Hunter, David J.

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Cambridge, MA 02138 USA

来源：

BMC CANCER | 2007年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2407-7-175

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results. Methods: We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. Results: No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer. Conclusion: Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.

引用

页数：6

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