Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting

被引:30
作者
Gu, Yawei [1 ]
Forget, Aurelien [1 ]
Shastri, V. Prasad [1 ,2 ]
机构
[1] Univ Freiburg, Inst Macromol Chem, D-79104 Freiburg, Germany
[2] Univ Freiburg, Bioss Ctr Biol Signalling Studies, D-79104 Breisgau, Germany
关键词
immunomodulation; instructive bioinks; organotypic vasculature; proregenerative bioinks; standardization; EXTRACELLULAR-MATRIX; TISSUE; HYDROGELS; ALGINATE; AGAROSE; CONSTRUCTS; MECHANOTRANSDUCTION; BIOMATERIALS; ANGIOGENESIS; MACROPHAGES;
D O I
10.1002/advs.202103469
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
3D-bioprinting (3DBP) possesses several elements necessary to overcome the deficiencies of conventional tissue engineering, such as defining tissue shape a priori, and serves as a bridge to clinical translation. This transformative potential of 3DBP hinges on the development of the next generation of bioinks that possess attributes for clinical use. Toward this end, in addition to physicochemical characteristics essential for printing, bioinks need to possess proregenerative attributes, while enabling printing of stable structures with a defined biological function that survives implantation and evolves in vivo into functional tissue. With a focus on bioinks for extrusion-based bioprinting, this perspective review advocates a rigorous biology-based approach to engineering bioinks, emphasizing efficiency, reproducibility, and a streamlined translation process that places the clinical endpoint front and center. A blueprint for engineering the next generation of bioinks that satisfy the aforementioned performance criteria for various translational levels (TRL1-5) and a characterization tool kit is presented.
引用
收藏
页数:15
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