Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma

被引：0
|
作者：
Zhang, Junbo [1 ]
He, Xue [2 ]
Ma, Yueying [4 ]
Liu, Yanli [2 ]
Shi, Huaiyin [3 ]
Guo, Weiwei [2 ]
Liu, Liangfa [4 ]
机构：
[1] Peking Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100853, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
[4] Capital Med Univ, Beijing Friendship Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100050, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 01期
关键词：
Laryngeal squamous cell carcinoma; ROCK; Y-27632; tumor growth; lymph node metastasis; RHO-KINASE; IN-VIVO; RHO/ROCK PATHWAY; CANCER CELLS; INVASION; TUMOR; METASTASIS; EXPRESSION; MIGRATION; PROTEIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Rho-associated coiled-coil containing protein kinase (ROCK) over-expression has been implicated in the progression of many tumor types. The aim of this study was to explore the roles of ROCK1 and ROCK2 in human laryngeal squamous cell carcinoma (LSCC). ROCK1 and ROCK2 expression levels were examined in 50 cases of human LSCC samples by immunohistochemistry. Effects of ROCK1 and ROCK2 on LSCC cell proliferation and motility were investigated in the presence of the ROCK inhibitor Y-27632. The results showed that ROCK1 expression was positively correlated with tumor size and lymph node metastasis (P < 0.05); ROCK2 positively correlated with tumor size (P < 0.05). Inhibition of ROCK1 and ROCK2 by Y-27632 significantly inhibits proliferation, migration, and invasion of LSCC cells. Our data indicate that expression of ROCK1 and ROCK2 are closely associated with tumor growth and lymph node metastasis of LSCC. Thus, these two ROCK isoforms may be useful as molecular makers for LSCC diagnosis and may be useful therapeutic targets as well.
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收藏
页码：244 / 251
页数：8
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