Separating target particles or cells from a heterogeneous mixture is often critical to many chemical and biomedical applications. Pinched flow fractionation (PFF) is a microfluidic technique that utilizes the laminar flow profile to continuously separate particles by size. We demonstrate that the flow-induced inertial lift force in microchannels can be exploited to significantly increase the particle displacement in PFF due to its strong size dependence. This inertia-enhanced PFF (iPFF) technique can offer at least one-order-of-magnitude higher particle throughput than PFF does at the same sheath flow rate. Moreover, it is able to work effectively in a large range of Reynolds number that spans more than 1 order of magnitude in the current study. In addition, iPFF is found to work most effectively in a rectangular microchannel with a width-to-height aspect ratio of around 2.
机构:
Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Gossett, Daniel R.
;
Weaver, Westbrook M.
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Weaver, Westbrook M.
;
Mach, Albert J.
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Mach, Albert J.
;
Hur, Soojung Claire
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Calif NanoSyst Inst, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Hur, Soojung Claire
;
Tse, Henry Tat Kwong
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Tse, Henry Tat Kwong
;
Lee, Wonhee
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Lee, Wonhee
;
Amini, Hamed
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Amini, Hamed
;
Di Carlo, Dino
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Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
机构:
Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90095 USA
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Gossett, Daniel R.
;
Weaver, Westbrook M.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Weaver, Westbrook M.
;
Mach, Albert J.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Mach, Albert J.
;
Hur, Soojung Claire
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h-index: 0
机构:
Calif NanoSyst Inst, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Hur, Soojung Claire
;
Tse, Henry Tat Kwong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Tse, Henry Tat Kwong
;
Lee, Wonhee
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Lee, Wonhee
;
Amini, Hamed
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Amini, Hamed
;
Di Carlo, Dino
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
Calif NanoSyst Inst, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA