Inertia-Enhanced Pinched Flow Fractionation

被引:63
作者
Lu, Xinyu [1 ]
Xuan, Xiangchun [1 ]
机构
[1] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA
关键词
CONTINUOUS PARTICLE SEPARATION; CONTINUOUS SIZE SEPARATION; CELL-SEPARATION; POISEUILLE FLOW; SPHERICAL-PARTICLES; LIFT; MIGRATION; MICROFLUIDICS; CHANNEL; PROFILE;
D O I
10.1021/acs.analchem.5b00752
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Separating target particles or cells from a heterogeneous mixture is often critical to many chemical and biomedical applications. Pinched flow fractionation (PFF) is a microfluidic technique that utilizes the laminar flow profile to continuously separate particles by size. We demonstrate that the flow-induced inertial lift force in microchannels can be exploited to significantly increase the particle displacement in PFF due to its strong size dependence. This inertia-enhanced PFF (iPFF) technique can offer at least one-order-of-magnitude higher particle throughput than PFF does at the same sheath flow rate. Moreover, it is able to work effectively in a large range of Reynolds number that spans more than 1 order of magnitude in the current study. In addition, iPFF is found to work most effectively in a rectangular microchannel with a width-to-height aspect ratio of around 2.
引用
收藏
页码:4560 / 4565
页数:6
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