Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study

被引：144

作者：

Ofori, Edward ^{[1
]}

Pasternak, Ofer ^{[2
,3
]}

Planetta, Peggy J. ^{[1
]}

Burciu, Roxana ^{[1
]}

Snyder, Amy ^{[1
]}

Febo, Marcelo ^{[4
]}

Golde, Todd E. ^{[5
]}

Okun, Michael S. ^{[6
]}

Vaillancourt, David E. ^{[1
,6
,7
]}

机构：

[1] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA

[4] Univ Florida, Dept Neurosci, Ctr Translat Res Neurodegenerat Dis, McKnight Brain Inst, Gainesville, FL 32610 USA

[5] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA

[6] Univ Florida, Dept Neurol, Ctr Movement Disorders & Neurorestorat, Gainesville, FL USA

[7] Univ Florida, Dept Biomed Engn, Gainesville, FL USA

来源：

NEUROBIOLOGY OF AGING | 2015年 / 36卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Substantia nigra; Parkinson's disease; Diffusion MRI; Free-water mapping; DIFFUSION-TENSOR MRI; GROWTH-FACTOR-ALPHA; NIGROSTRIATAL SYSTEM; CEREBROSPINAL-FLUID; BRAIN; ATROPHY; DEGENERATION; IMPAIRMENT; PATHOLOGY; PATTERNS;

D O I：

10.1016/j.neurobiolaging.2014.10.029

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson's disease. It is the case, however, that partial volume effects from free water can bias diffusion measurements. The bi-tensor diffusion model was introduced to quantify the contribution of free water and eliminates its bias on estimations of tissue microstructure. Here, we test the hypothesis that free water is elevated in the substantia nigra for Parkinson's disease compared with control subjects. This hypothesis was tested between large cohorts of Parkinson's disease and control participants in a single-site study and validated against a multisite study using multiple scanners. The fractional volume of free water was increased in the posterior region of the substantia nigra in Parkinson's disease compared with control subjects in both the single-site and multi-site studies. We did not observe changes in either cohort for free-water-corrected fractional anisotropy or free-water-corrected mean diffusivity. Our findings provide new evidence that the free-water index reflects alteration of the substantia nigra in Parkinson's disease, and this was evidenced across both single-site and multi-site cohorts. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：1097 / 1104

页数：8

共 48 条

[1] Analysis of partial volume effects in diffusion-tensor MRI [J].

Alexander, AL ;

Hasan, KM ;

Lazar, M ;

Tsuruda, JS ;

Parker, DL .

MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (05) :770-780

[2] Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure [J].

Barcia, C ;

Bahillo, AS ;

Fernández-Villalba, E ;

Bautista, V ;

Poza, MPY ;

Fernández-Barreiro, A ;

Hirsch, EC ;

Herrero, MT .

GLIA, 2004, 46 (04) :402-409

[3]

Basser PJ, 1996, J MAGN RESON SER B, V111, P209, DOI [10.1006/jmrb.1996.0086, 10.1016/j.jmr.2011.09.022]

[4] Characterization and propagation of uncertainty in diffusion-weighted MR imaging [J].

Behrens, TEJ ;

Woolrich, MW ;

Jenkinson, M ;

Johansen-Berg, H ;

Nunes, RG ;

Clare, S ;

Matthews, PM ;

Brady, JM ;

Smith, SM .

MAGNETIC RESONANCE IN MEDICINE, 2003, 50 (05) :1077-1088

[5] CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment [J].

Berlot, Rok ;

Metzler-Baddeley, Claudia ;

Jones, Derek K. ;

O'Sullivan, Michael J. .

NEUROIMAGE, 2014, 92 :27-35

[6] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[7] Case control study of diffusion tensor imaging in Parkinson's disease [J].

Chan, L-L ;

Rumpel, H. ;

Yap, K. ;

Lee, E. ;

Loo, H-V ;

Ho, G-L ;

Fook-Chong, S. ;

Yuen, Y. ;

Tan, E-K .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (12) :1383-1386

[8] The substantia nigra of the human brain - II. Patterns of loss of dopamine-containing neurons in Parkinson's disease [J].

Damier, P ;

Hirsch, EC ;

Agid, Y ;

Graybiel, AM .

BRAIN, 1999, 122 :1437-1448

[9] Imaging nigral pathology and clinical progression in Parkinson's disease [J].

Du, Guangwei ;

Lewis, Mechelle M. ;

Sen, Suman ;

Wang, Jianli ;

Shaffer, Michele L. ;

Styner, Martin ;

Yang, Qing X. ;

Huang, Xuemei .

MOVEMENT DISORDERS, 2012, 27 (13) :1636-1643

[10] Combined R2*and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease [J].