Peptidomimetics and Peptide-Based Blockbuster Drugs

被引：12

作者：

Han, Jianlin ^{[1
]}

Konno, Hiroyuki ^{[2
]}

Sato, Tatsunori ^{[3
]}

Izawa, Kunisuke ^{[3
]}

Soloshonok, Vadim A. ^{[4
,5
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Co Innovat Ctr Efficient Proc & Utilizat, Nanjing 210037, Jiangsu, Peoples R China

[2] Yamagata Univ, Grad Sch Sci & Engn, Dept Biol Engn, Yonezawa, Yamagata 9928510, Japan

[3] Hamari Chem Ltd, Suminoe Ku, 1-19-40 Nankokita, Osaka 5590034, Japan

[4] Univ Basque Country UPV EHU, Fac Chem, Dept Organ Chem 1, Paseo Manuel Lardizabal 3, San Sebastian 20018, Spain

[5] Basque Fdn Sci, IKERBASQUE, Alameda Urquijo 36-5,Plaza Bizkaia, Bilbao 48011, Spain

来源：

CURRENT ORGANIC CHEMISTRY | 2021年 / 25卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Tailor-made amino acids; blockbuster drugs; peptidomimetic; peptides; modern pharmaceuticals; drug design and development; asymmetric synthesis; ALPHA-AMINO-ACIDS; DYNAMIC KINETIC RESOLUTION; CYTOCHROME-P450; CYP; 3A; ASYMMETRIC-SYNTHESIS; SELF-DISPROPORTIONATION; NI(II) COMPLEXES; BIOLOGICAL EVALUATION; PROTEASOME INHIBITOR; S/R INTERCONVERSION; DIAMINE INHIBITORS;

D O I：

10.2174/1385272825666210610155047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs' residues are frequently found in the structures of small molecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.

引用

页码：1627 / 1658

页数：32

共 135 条

[1]

Bacon E. M., 2012, Patent No. [WO2012068234, 2012068234, 2012/068234]

[2]

Bacon E.M., 2013, PCT Int. Appl, Patent No. [WO2013075029, 2013075029]

[3]

BAUER W, 1982, LIFE SCI, V31, P1133, DOI 10.1016/0024-3205(82)90087-X

[4] Asymmetric copper-catalyzed synthesis of α-amino boronate esters from N-tert-butanesulfinyl aldimines [J].