Boron doped graphdiyne: A metal-free peroxidase mimetic nanozyme for antibacterial application

被引:102
作者
Bi, Xuelong [1 ,3 ]
Bai, Qiang [1 ]
Wang, Lina [3 ]
Du, Fanglin [1 ]
Liu, Manhong [1 ]
Yu, William W. [4 ]
Li, Siheng [5 ]
Li, Jiaqiang [2 ]
Zhu, Zhiling [1 ]
Sui, Ning [1 ,2 ]
Zhang, Jin [2 ]
机构
[1] Qingdao Univ Sci & Technol, Coll Mat Sci & Engn, Qingdao 266042, Peoples R China
[2] Peking Univ, Coll Chem & Mol Engn, Ctr Nanochem, Beijing Sci & Engn Ctr Nanocarbons,Natl Lab Mol S, Beijing 100871, Peoples R China
[3] Qingdao Univ Sci & Technol, Coll Environm & Safety Engn, Qingdao 266042, Peoples R China
[4] Louisiana State Univ Shreveport, Dept Chem & Phys, One Univ Pl, Shreveport, LA 71115 USA
[5] Univ Houston, Dept Chem, Houston, TX 77204 USA
基金
中国国家自然科学基金;
关键词
graphdiyne; nanozyme; metal-free; antibacterial; wound healing; FREE ELECTROCATALYST; NANOMATERIALS;
D O I
10.1007/s12274-021-3685-4
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The abuse of conventional antibiotics leads to increasing bacterial resistance. Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities, showing remarkable potential as a next generation nanobactericide. Graphdiyne (GDY) is a burgeoning two-dimensional (2D) carbon allotrope with intriguing physicochemical properties, holding a great promise as a metal-free nanozyme. In this study, a boron doped GDY nanosheet (B-GDY) was constructed to simulate the performance of peroxidase (POD). By promoting the decomposition of H2O2 to produce reactive oxygen species (ROS), the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY. In-depth density functional theory (DFT) calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H2O2 decomposition reaction. Notably, B-GDY contributes to significant wound healing and excellent biocompatibility, reducing the biological burden. The design of this nanozyme opens a new avenue for the development of alternative antibiotics.
引用
收藏
页码:1446 / 1454
页数:9
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