Digital innovations have now made it possible for healthcare organization to transform their task to use digital devices to access medical information, monitor vital signs tests, and carry out wide range of tasks to provide quality care. The tendency of information security incidents might increase due to this transformation. One of the solutions is by embedding employees with knowledge regarding information security. Previous literatures have examined knowledge management (KM) in general and omitted healthcare informatics perspective. However, knowledge sharing between employees in healthcare organization can be challenging as their background and expertise domains differ. The purpose of this paper is to investigate the role of key resistance factors in knowledge sharing towards information security culture in healthcare organization. Based on the secondary data collected, the key resistance factors identified are behavior, lack of trust, lack of communication, low security awareness, personality differences, cultural differences, lack of top management commitment, and openness to experience. A conceptual model was proposed to represent the key resistance factors identified. This in-progress study will proceed in testing the proposed conceptual model in selected healthcare organizations in Malaysia.