Cervical cancer response to neoadjuvant chemoradiotherapy: MRI assessment compared with surgery

被引:15
作者
Gui, Benedetta [1 ]
Valentini, Anna Lia [1 ]
Micco, Maura [1 ]
D'Agostino, Giuseppe Roberto [2 ]
Tagliaferri, Luca [2 ]
Zannoni, Gian Franco [3 ]
Fanfani, Francesco [4 ]
Manfredi, Riccardo [5 ]
Bonomo, Lorenzo [1 ]
机构
[1] Univ Cattolica Sacro Cuore, Dept Bioimaging & Radiol Sci, Agostino Gemelli Hosp, Lgo F Vito 8, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Agostino Gemelli Hosp, Dept Radiat Oncol, Rome, Italy
[3] Univ Cattolica Sacro Cuore, Agostino Gemelli Hosp, Dept Pathol, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Agostino Gemelli Hosp, Dept Gynecol Oncol, Rome, Italy
[5] Univ Verona, Dept Radiol, Policlin GB Rossi, I-37100 Verona, Italy
关键词
Cervical cancer; magnetic resonance imaging (MRI); chemoradiotherapy; post-treatment evaluation; tumor; inflammation; RADIATION-THERAPY; RADICAL SURGERY; CONCURRENT CHEMORADIOTHERAPY; IMAGING ASSESSMENT; CARCINOMA; TUMOR; RADIOTHERAPY; DIFFERENTIATION; CHEMORADIATION; HYSTERECTOMY;
D O I
10.1177/0284185115617346
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background Imaging findings of residual cervical tumor after chemoradiotherapy can closely resemble those of post-irradiation inflammation. Purpose To determine the diagnostic performance of magnetic resonance imaging (MRI) in evaluating residual disease after chemoradiotherapy in patients with locally advanced cervical carcinoma (LACC). Material and Methods Retrospective analysis of prospectively collected data from 41 patients with histopathologically proven LACC (International Federation of Gynecology and Obstetrics stage IB2) who underwent MRI before and after chemoradiotherapy. At each examination, a qualitative and semi-quantitative analysis of primary tumor, including tumor volume and signal intensity were assessed on T2-weighted (T2W) images. All patients had surgery after post-chemoradiotherapy MRI. MRI and histopathologic results were compared. Results All patients showed significant difference in tumor volume and signal intensity between pre- and post-chemoradiotherapy MRI (P<0.0001). According to pathology, 27/41 (66%) patients had true negative and 2/41 (5%) had true positive post-chemoradiotherapy MRI. Eleven out of 41 (27%) patients showed inflammation with false positive post-chemoradiotherapy MRI and 1/41 (2%) had a false negative post-chemoradiotherapy MRI. Sensitivity, specificity, accuracy, positive predictive values, and negative predictive values of post-chemoradiotherapy MRI in predicting residual disease were 69%, 71%, 71%, 15%, and 96%, respectively. Conclusion The differentiation of residual tumor from post-irradiation inflammation with early post- chemoradiotherapy MRI (within 28-60 days) is difficult with a high risk of false positive results. Combination of qualitative and semi-quantitative analysis does not improve the accuracy. Conversely, post-chemoradiotherapy MRI has a high negative predictive value with a low risk of false negative results. The role of conventional MRI combined with functional techniques should be evaluated.
引用
收藏
页码:1123 / 1131
页数:9
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