Diversifying vancomycin via chemoenzymatic strategies

被引：84
作者：
Fu, X [1 ]
Albermann, C [1 ]
Zhang, CS [1 ]
Thorson, JS [1 ]
机构：
[1] Univ Wisconsin, Sch Pharm, Pharmaceut Sci Div, Lab Biosynthet Chem, Madison, WI 53705 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 08期
关键词：
D O I：
10.1021/ol0501626
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The rapid diversification of glycopeptides via glycorandomization reveals that significantly diverse substitutions are tolerated and suggests there may be a synergistic benefit to the construction of mechanistically related natural product core scaffold fusions. This work also further highlights the utility of chemoenzymatic approaches to diversify complex natural product architectures.
引用
收藏
页码：1513 / 1515
页数：3
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