Stem cells: The therapeutic role in the treatment of diabetes mellitus

被引：1

作者：

Adams, Gary G. ^{[1
,2
,3
]}

Buttery, Lee ^{[2
]}

Stolnik, Snow ^{[2
]}

Morris, Gordon ^{[3
]}

Harding, Stephen ^{[3
]}

Wang, Nan

机构：

[1] Univ Nottingham, Fac Med & Hlth Sci, Insulin Diabet Expt Res Grp, Nottingham NG7 2RD, England

[2] Univ Nottingham, Sch Pharm, Fac Sci, Nottingham NG7 2RD, England

[3] Univ Nottingham, Sch Biosci, Natl Ctr Macromol Hydrodynam, Sutton LE12 5RD, Surrey, England

来源：

BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 27 | 2010年 / 27卷

关键词：

IN-VITRO DIFFERENTIATION; EMBRYOID BODY FORMATION; INSULIN-PRODUCING CELLS; PRIMORDIAL GERM-CELLS; SELF-RENEWAL; DEVELOPMENTAL BIOLOGY; MOUSE TERATOCARCINOMA; SIGNALING MAINTAINS; DEFINITIVE ENDODERM; BETA-CATENIN;

D O I：

10.1080/02648725.2010.10648154

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The unlimited proliferative ability and plasticity to generate other cell types ensures that stem cells represent a dynamic system apposite for the identification of new molecular targets and the production and development of novel drugs. These cell lines derived from embryos could be used as a model for the study of basic and applied aspects in medical therapeutics, environmental mutagenesis and disease management. As a consequence, these can be tested for safety or to predict or anticipate potential toxicity in humans. Human ES cell lines may, therefore, prove clinically relevant to the development of safer and more effective drugs for patients presenting with diabetes mellitus.

引用

页码：285 / 303

页数：19

共 117 条

[1] Stem cell test: A practical tool in toxicogenomics [J].