Copper-catalyzed redox neutral ketoalkylation of Csp2-H bonds via C-C bond cleavage

被引：11
|
作者：
Chen, He
Guo, Li-Na
Sun, Qing-Xin
Chen, Lei
Tao, Jing-Qi
Gao, Pin [1 ]
机构：
[1] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Sch Chem, Dept Chem, Xian 710049, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 20期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
HETEROAROMATIC N-OXIDES; CYCLOALKYLSILYL PEROXIDES; H FUNCTIONALIZATION; ALKYLATION; INHIBITORS; QUINOXALIN-2(1H)-ONES; DERIVATIVES; CYCLIZATION; QUINONES; RADICALS;
D O I：
10.1039/d1qo00882j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient copper-catalyzed ketoalkylation of Csp(2)-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.
引用
收藏
页码：5866 / 5871
页数：6
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