Synthesis and Inhibitory Activity Evaluation of 2,6-Disubstituted Purine Derivatives

被引：2

作者：

Liu, Hongxia ^{[1
,2
]}

Li, Libo ^{[3
]}

Qurat-ul-ain, Shaikh ^{[1
]}

Jiang, Tao ^{[1
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Shandong, Peoples R China

[2] Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Heilongjiang, Peoples R China

[3] Qiqihar Med Univ, Dept Pharmacol, Qiqihar 161006, Heilongjiang, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 02期

关键词：

ADENINE-DERIVATIVES; POTENT;

D O I：

10.1002/jhet.1959

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2,6-disubstituted purine derivatives were designed and synthesized from 2,6-dichloropurine. The structures of target compounds were determined by H-1-NMR, C-13-NMR, and HRMS. The synthesized compounds were evaluated for their inhibitory activities against lung cancer cell lines of A549 and liver cancer cell lines of Bel-7402. 2-(4-Benzyloxy-phenylamino)-6-(cyclohexylamino)purine(3), 2-(4-chloro-phenylamino)-6-(n-butylamino)purine (5), 2-(4-morpholinoamino)-6-(4-hydroxy-phenylamino)purine (9), and 2-(4-O-galactosyl-phenylamino)-6-(cyclohexylamino)purine (12) exhibited moderate inhibitory activity.

引用

页码：473 / 477

页数：5

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