Ligand-controlled, Pd/CuH-catalyzed reductive cross-coupling of terminal alkenes and N-heteroaryl bromides

被引：9

作者：

Seo, Sanghyup ^{[1
]}

Kim, Donghyeon ^{[1
]}

Kim, Hyunwoo ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol KAIST, Dept Chem, Daejeon 34141, South Korea

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 85期

基金：

新加坡国家研究基金会;

关键词：

NITROGEN-HETEROCYCLES; PALLADIUM; TRANSMETALATION; ESTERS;

D O I：

10.1039/d1cc04833c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reductive cross-coupling of terminal alkenes and N-heterocyclic bromides has been demonstrated by ligand optimization of Pd and CuH catalysis. The optimized ligands are Briphos, a pi-acceptor monodentate phosphorus ligand, for Pd catalysis and DTB-DPPBz, a sterically bulky bidentate phosphorus ligand, for CuH catalysis. These conditions were further applied to the gram-scale production of clathryimine B.

引用

页码：11240 / 11243

页数：4

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