The Role of Hepatic Arterial Infusion Chemotherapy in the Treatment of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

被引：22
作者：
Li, Shengzhou [1 ]
Xu, Jiaxuan [2 ]
Zhang, Hongya [3 ]
Hong, Jiaze [2 ]
Si, Yuexiu [4 ]
Yang, Tong [5 ]
He, Yujing [2 ]
Ng, Derry Minyao [6 ]
Zheng, Dingcheng [7 ]
机构：
[1] Ningbo Yinzhou 2 Hosp, Emergency Med Ctr, Ningbo, Peoples R China
[2] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
[3] Ningbo Yinzhou 2 Hosp, Thyroid & Breast Surg, Ningbo, Peoples R China
[4] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou, Peoples R China
[5] Univ Chinese Acad Sci, HwaMei Hosp, Dept Tumor HIFU Therapy, Ningbo, Peoples R China
[6] Ningbo Univ, Med Coll, Ningbo, Peoples R China
[7] Univ Chinese Acad Sci, HwaMei Hosp, Dept Gen Surg, Ningbo, Peoples R China
来源：
CHEMOTHERAPY | 2021年 / 66卷 / 04期
关键词：
Hepatocellular carcinoma; Hepatic arterial infusion chemotherapy; Meta-analysis; PRIMARY LIVER-CANCER; SORAFENIB; RESECTION; CISPLATIN; EFFICACY; 5-FLUOROURACIL; MECHANISMS; CELLS;
D O I：
10.1159/000518257
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The main aim of this study was to investigate comprehensively the clinical effect of hepatic arterial infusion chemotherapy (HAIC) on patients suffering from hepatocellular carcinoma (HCC). Methods: The following electronic databases were searched for eligible articles published from inception to July 2020: PubMed, Web of Science, Embase, and Cochrane Library. The main final indicators were overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Results: A total of 26 studies entailing 4,506 cases were included for a meta-analysis. The results showed that HAIC could improve advanced HCC patients' OS (HR, 0.49; 95% CI: 0.37-0.61) and PFS (HR, 0.52; 95% CI: 0.36-0.68). Remarkably, compared with Japan (HR, 0.58) and Korea (HR, 0.54), for the unresectable HCC patients, the HAIC group achieved higher efficacy on OS than the control group in China (HR, 0.24). The resectable HCC patients, who received HAIC adjuvant chemotherapy, exhibited favorable prognosis for OS (HR, 0.58; 95% CI: 0.27-0.88) and DFS (HR, 0.49; 95% CI: 0.31-0.68). Conclusion: HAIC improved long-term survival for both resectable and unresectable HCC patients in comparison with other therapies. However, the clinical effect of HAIC needs to be ascertained by large-scale well-designed studies.
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页码：124 / 133
页数：10
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[31]  
Moher D, 2009, PLOS MED, V6, DOI [10.1136/bmj.b2700, 10.1371/journal.pmed.1000097, 10.1016/j.ijsu.2010.02.007, 10.1136/bmj.i4086, 10.1186/2046-4053-4-1, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.b2535]
[32]   Sorafenib versus Hepatic Arterial Infusion Chemotherapy as Initial Treatment for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombosis [J].
Moriguchi, Michihisa ;
Aramaki, Takeshi ;
Nishiofuku, Hideyuki ;
Sato, Rui ;
Asakura, Koiku ;
Yamaguchi, Kanji ;
Tanaka, Toshihiro ;
Endo, Masahiro ;
Itoh, Yoshito .
LIVER CANCER, 2017, 6 (04) :275-286
[33]   Efficacy of bi-monthly hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma [J].
Moriya, Kei ;
Namisaki, Tadashi ;
Sato, Shinya ;
Douhara, Akitoshi ;
Furukawa, Masanori ;
Kawaratani, Hideto ;
Kaji, Kosuke ;
Kitade, Mitsuteru ;
Shimozato, Naotaka ;
Sawada, Yasuhiko ;
Seki, Kenichiro ;
Saikawa, Soichiro ;
Takaya, Hiroaki ;
Akahane, Takemi ;
Mitoro, Akira ;
Okura, Yasushi ;
Yamao, Junichi ;
Yoshiji, Hitoshi .
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2018, 9 (04) :741-+
[34]   Adjuvant arterial infusion chemotherapy after resection of hepatocellular carcinoma with portal thrombosis: a pilot study [J].
Niguma, T ;
Mimura, T ;
Tutui, N .
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 2005, 12 (03) :249-253
[35]   Adjuvant Hepatic Arterial Infusion Chemotherapy after Hepatic Resection of Hepatocellular Carcinoma With Macroscopic Vascular Invasion [J].
Nitta, Hidetoshi ;
Beppu, Toru ;
Imai, Katsunori ;
Hayashi, Hiromitsu ;
Chikamoto, Akira ;
Baba, Hideo .
WORLD JOURNAL OF SURGERY, 2013, 37 (05) :1034-1042
[36]   Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the Nationwide Survey of Primary Liver Cancer in Japan [J].
Nouso, K. ;
Miyahara, K. ;
Uchida, D. ;
Kuwaki, K. ;
Izumi, N. ;
Omata, M. ;
Ichida, T. ;
Kudo, M. ;
Ku, Y. ;
Kokudo, N. ;
Sakamoto, M. ;
Nakashima, O. ;
Takayama, T. ;
Matsui, O. ;
Matsuyama, Y. ;
Yamamoto, K. .
BRITISH JOURNAL OF CANCER, 2013, 109 (07) :1904-1907
[37]   Sorafenib Plus Hepatic Arterial Infusion Chemotherapy in Advanced Hepatocellular Carcinoma A Systematic Review and Meta-Analysis [J].
Ouyang, Guoqing ;
Pan, Guangdong ;
Xu, Honglai ;
Wu, Yongrong ;
Liu, Zhen ;
Lu, Wuhang ;
Yi, Bin ;
Chen, Xiang .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 2020, 54 (08) :675-681
[38]   A comparative study between sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis [J].
Song, Do Seon ;
Song, Myeong Jun ;
Bae, Si Hyun ;
Chung, Woo Jin ;
Jang, Jae Young ;
Kim, Young Seok ;
Lee, Sae Hwan ;
Park, Jun Yong ;
Yim, Hyung Joon ;
Cho, Sung Bum ;
Park, Soo Young ;
Yang, Jin Mo .
JOURNAL OF GASTROENTEROLOGY, 2015, 50 (04) :445-454
[39]   Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma [J].
Song, Myeong Jun .
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (13) :3843-3849
[40]   Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses [J].
Stang, Andreas .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2010, 25 (09) :603-605
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