The Role of Hepatic Arterial Infusion Chemotherapy in the Treatment of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

被引:22
作者
Li, Shengzhou [1 ]
Xu, Jiaxuan [2 ]
Zhang, Hongya [3 ]
Hong, Jiaze [2 ]
Si, Yuexiu [4 ]
Yang, Tong [5 ]
He, Yujing [2 ]
Ng, Derry Minyao [6 ]
Zheng, Dingcheng [7 ]
机构
[1] Ningbo Yinzhou 2 Hosp, Emergency Med Ctr, Ningbo, Peoples R China
[2] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
[3] Ningbo Yinzhou 2 Hosp, Thyroid & Breast Surg, Ningbo, Peoples R China
[4] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou, Peoples R China
[5] Univ Chinese Acad Sci, HwaMei Hosp, Dept Tumor HIFU Therapy, Ningbo, Peoples R China
[6] Ningbo Univ, Med Coll, Ningbo, Peoples R China
[7] Univ Chinese Acad Sci, HwaMei Hosp, Dept Gen Surg, Ningbo, Peoples R China
关键词
Hepatocellular carcinoma; Hepatic arterial infusion chemotherapy; Meta-analysis; PRIMARY LIVER-CANCER; SORAFENIB; RESECTION; CISPLATIN; EFFICACY; 5-FLUOROURACIL; MECHANISMS; CELLS;
D O I
10.1159/000518257
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The main aim of this study was to investigate comprehensively the clinical effect of hepatic arterial infusion chemotherapy (HAIC) on patients suffering from hepatocellular carcinoma (HCC). Methods: The following electronic databases were searched for eligible articles published from inception to July 2020: PubMed, Web of Science, Embase, and Cochrane Library. The main final indicators were overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Results: A total of 26 studies entailing 4,506 cases were included for a meta-analysis. The results showed that HAIC could improve advanced HCC patients' OS (HR, 0.49; 95% CI: 0.37-0.61) and PFS (HR, 0.52; 95% CI: 0.36-0.68). Remarkably, compared with Japan (HR, 0.58) and Korea (HR, 0.54), for the unresectable HCC patients, the HAIC group achieved higher efficacy on OS than the control group in China (HR, 0.24). The resectable HCC patients, who received HAIC adjuvant chemotherapy, exhibited favorable prognosis for OS (HR, 0.58; 95% CI: 0.27-0.88) and DFS (HR, 0.49; 95% CI: 0.31-0.68). Conclusion: HAIC improved long-term survival for both resectable and unresectable HCC patients in comparison with other therapies. However, the clinical effect of HAIC needs to be ascertained by large-scale well-designed studies.
引用
收藏
页码:124 / 133
页数:10
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