ISG20 serves as a potential biomarker and drives tumor progression in clear cell renal cell carcinoma

被引:41
作者
Xu, Tianbo [1 ]
Ruan, Hailong [1 ]
Gao, Su [2 ]
Liu, Jingchong [1 ]
Liu, Yuenan [1 ]
Song, Zhengshuai [3 ]
Cao, Qi [1 ]
Wang, Keshan [1 ]
Bao, Lin [1 ]
Liu, Di [1 ]
Tong, Junwei [1 ]
Shi, Jian [1 ]
Liang, Huageng [1 ]
Yang, Hongmei [4 ]
Chen, Ke [1 ]
Zhang, Xiaoping [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan 430022, Peoples R China
[3] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Urol, Wuhan 430022, Peoples R China
[4] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathogen Biol, Wuhan 430030, Peoples R China
来源
AGING-US | 2020年 / 12卷 / 02期
基金
中国国家自然科学基金;
关键词
clear cell renal cell carcinoma; ISG20; biomarker; tumor progression; bioinformatics; SINGLE-STRANDED RNA; REGULARIZATION PATHS; EXONUCLEASE ISG20; KIDNEY CANCER; EXPRESSION; MMP-9; ACTIVATION; ANGIOGENESIS; FIBROBLASTS; ADHESION;
D O I
10.18632/aging.102714
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies and lacks reliable biomarkers for diagnosis and prognosis, which results in high incidence and mortality rates of ccRCC. In this study, ISG20, HJURP, and FOXM1 were identified as hub genes via weighted gene co-expression network analysis (WGCNA) and Cox regression analysis. Samples validation showed that only ISG20 was up-regulated in ccRCC. Therefore, ISG20 was selected for further study. High ISG20 expression was associated with poor overall survival and disease-free survival. Furthermore, the expression of ISG20 could effectively differentiate ccRCC from normal tissues and was positively correlated to clinical stages. Functional experiments proved that knockdown of ISG20 expression could obviously inhibit cell growth, migration, and invasion in ccRCC cells. To find the potential mechanisms of ISG20, gene set enrichment analysis (GSEA) was performed and revealed that high expression of ISG20 was significantly involved in metastasis and cell cycle pathways. In addition, we found that ISG20 could regulate the expression of MMP9 and CCND1. In conclusion, these findings suggested that ISG20 promoted cell proliferation and metastasis via regulating MMP9/CCND1 expression and might serve as a potential biomarker and therapeutic target in ccRCC.
引用
收藏
页码:1789 / 1808
页数:20
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