A Thai Reference for Normal Fetal Nasal Bone Length at 11-13(+6) Weeks Gestation

被引：4
作者：
Pruksanusak, N. [1 ]
Suwanrath, C. [1 ]
Kor-anantakul, O. [1 ]
Suntharasaj, T. [1 ]
Hanprasertpong, T. [1 ]
Pranpnus, S. [1 ]
Geater, A. F. [1 ]
机构：
[1] Prince Songkla Univ, Fac Med, Dept Obstet & Gynecol, Hat Yai 90110, Songkhla, Thailand
来源：
GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2012年 / 73卷 / 03期
关键词：
Down's syndrome; Nasal bone; First-trimester measurement; Ethnicity; CHINESE POPULATION; DOWN-SYNDROME; ULTRASOUND; TRISOMY-21; HYPOPLASIA; PREGNANCY; FETUSES; ABSENCE;
D O I：
10.1159/000333238
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Aim: The purpose of this study was to establish a Thai reference for normal fetal nasal bone length (NBL) at 11-13(+6) weeks gestation. Methods: The fetal nasal bone was measured by sonography in pregnant women at 11-13(+6) weeks gestation. All neonates who showed normal karyotypes were examined after delivery to confirm the absence of congenital abnormalities. Results: A total of 255 pregnant women were recruited. Forty-seven pregnant women were excluded from the analysis because of technically unsatisfactory examination or absent nasal bone and chromosomal abnormalities. The mean +/- SD of NBL was 1.79 +/- 0.33 mm and increased significantly with crown-rump length (CRL) and gestational age (p < 0.001). The best-fit equation for NBL in euploid fetuses in relation to CRL was: NBL (mm) = (0.030 x CRL (mm)) - 0.016. Conclusion: NBL in Thai fetuses at 11-13(+6) weeks was found to be on average shorter than that in Caucasian, African-American and Chinese populations, but similar to those reported in Korean and Latin-American populations. Copyright (C) 2011 S. Karger AG, Basel
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页码：211 / 216
页数：6
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