Iron-catalyzed peroxidation-carbamoylation of alkenes with hydroperoxides and formamides via formyl C(sp2)-H functionalization

被引：34
作者：
Cheng, Jun-Kee [2 ]
Shen, Liang [2 ]
Wu, Liu-Hai [2 ]
Hu, Xu-Hong [1 ]
Loh, Teck-Peng [1 ,2 ]
机构：
[1] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Jiangsu, Peoples R China
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 95期
基金：
新加坡国家研究基金会;
关键词：
MONOXIDE-FREE AMINOCARBONYLATION; N-SUBSTITUTED FORMAMIDES; CARBON-CENTERED RADICALS; BOND FORMATION; CARBONYLATION-PEROXIDATION; C-H; 1,4-DICARBONYL COMPOUNDS; ORGANIC-SYNTHESIS; ARYL ISONITRILES; DIRECT ADDITION;
D O I：
10.1039/c7cc08074c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of beta-peroxy amides has been achieved. The beta-peroxy amide could serve as a synthetic precursor which was facilely converted to beta-hydroxy amide, beta-keto amide and beta-lactam following subsequent chemical transformation.
引用
收藏
页码：12830 / 12833
页数：4
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