Exploring Staphylococcus aureus pathways to disease for vaccine development

被引：30

作者：

DeDent, Andrea ^{[1
]}

Kim, Hwan Keun ^{[1
]}

Missiakas, Dominique ^{[1
]}

Schneewind, Olaf ^{[1
]}

机构：

[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2012年 / 34卷 / 02期

关键词：

MRSA; Iron; Coagulation; Immunomodulation; FACTOR-BINDING-PROTEIN; SURFACE DETERMINANT-B; OXIDATIVE STRESS RESISTANCE; HEME-DEGRADING ENZYMES; CLUMPING FACTOR; COMPLEMENT EVASION; IMMUNE-RESPONSE; CELL-WALL; MOLECULAR CHARACTERIZATION; SIDEROPHORE BIOSYNTHESIS;

D O I：

10.1007/s00281-011-0299-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus is a commensal of the human skin or nares and a pathogen that frequently causes skin and soft tissue infections as well as bacteremia and sepsis. Recent efforts in understanding the molecular mechanisms of pathogenesis revealed key virulence strategies of S. aureus in host tissues: bacterial scavenging of iron, induction of coagulation pathways to promote staphylococcal agglutination in the vasculature, and suppression of innate and adaptive immune responses. Advances in all three areas have been explored for opportunities in vaccine design in an effort to identify the critical protective antigens of S. aureus. Human clinical trials with specific subunit vaccines have failed, yet provide important insights for the design of future trials that must address the current epidemic of S. aureus infections with drug-resistant isolates (MRSA, methicillin-resistant S. aureus).

引用

页码：317 / 333

页数：17

共 188 条

[1] Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation [J].