Exclusive Enteral Nutrition: Clues to the Pathogenesis of Crohn's Disease

被引：4

作者：

Levine, Arie ^{[1
]}

机构：

[1] Tel Aviv Univ, Pediat Gastroenterol Unit, Wolfson Med Ctr, Holon, Israel

来源：

NUTRITION, GUT MICROBIOTA AND IMMUNITY: THERAPEUTIC TARGETS FOR IBD | 2014年 / 79卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; ESCHERICHIA-COLI; RISK-FACTORS; INTESTINAL PERMEABILITY; GUT MICROBIOTA; DIETARY-FAT; CHILDREN; MICE; GENETICS; INCREASE;

D O I：

10.1159/000360719

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease (CD) is a complex inherited disorder of unknown pathogenesis. Recent evidence suggests that CD may involve genetic or environmental factors that impair the normal innate immune system's ability to contain bacteria to the lumen. Multiple dietary components may impact on the resident flora, diminish or damage the mucous layer, increase intestinal permeability or increase the ability of pathobionts to adhere to epithelial cells or translocate across the epithelial barrier. This chapter reviews the possible effects of different dietary components present in the Western diet to affect bacterial clearance mechanisms, and offers a hypothetical model for an acquired bacterial clearance defect in CD. (C) 2014 Nestec Ltd., Vevey/S. Karger AG, Basel

引用

页码：131 / 140

页数：10

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