Highly-sensitive optical biosensor based on equal FSR cascaded microring resonator with intensity interrogation for detection of progesterone molecules

被引：33

作者：

Xie, Zhenyi ^{[1
]}

Cao, Ziwei ^{[1
]}

Liu, Yong ^{[1
]}

Zhang, Qingwen ^{[2
,3
]}

Zou, Jun ^{[4
]}

Shao, Liyang ^{[5
]}

Wang, Yi ^{[2
,3
]}

He, Jianjun ^{[1
]}

Li, Mingyu ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Ctr Integrated Optoelect, Coll Opt Sci & Engn, Hangzhou 310027, Peoples R China

[2] Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Peoples R China

[3] Wenzhou Med Univ, Sch Biomed Engn, Wenzhou 325001, Peoples R China

[4] Zhejiang Univ Technol, Coll Sci, Hangzhou 310023, Zhejiang, Peoples R China

[5] Southern Univ Sci & Technol, Dept Elect & Elect Engn, Shenzhen 518055, Peoples R China

来源：

OPTICS EXPRESS | 2017年 / 25卷 / 26期

基金：

中国国家自然科学基金;

关键词：

MACH-ZEHNDER INTERFEROMETER; DOUBLE-RING SENSORS; MILK; COWS;

D O I：

10.1364/OE.25.033193

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report a refractive index sensing system with a high sensitivity of 1579 dB/RIU and a low refractive index detection limit of 9.7 x 10(-6) RIU. The sensing system was based on cascaded-microring resonators (CMRR) using intensity interrogation. The free spectrum range (FSR) for the reference ring was designed to be equal to the sensing ring. The sensing ring of the CMRR was modified with molecularly imprinted polymers (MIPs) for the detection of progesterone. The achieved limit of detection (LOD) was as low as 83.5 fg/mL. (C) 2017 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：33193 / 33201

页数：9

共 26 条

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