Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles

被引：116

作者：

Ling, Daishun ^{[2
,3
]}

Park, Wooram ^{[1
]}

Park, Yong Il ^{[2
,3
]}

Lee, Nohyun ^{[2
,3
]}

Li, Fangyuan ^{[1
]}

Song, Changyeong ^{[2
,3
]}

Yang, Su-Geun ^{[6
]}

Choi, Seung Hong ^{[4
,5
]}

Na, Kun ^{[1
]}

Hyeon, Taeghwan ^{[2
,3
]}

机构：

[1] Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea

[2] Seoul Natl Univ, WCU Program Chem Convergence Energy & Environm C2, Seoul 151744, South Korea

[3] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[4] Seoul Natl Univ, Seoul Natl Univ Hosp, Seoul 110744, South Korea

[5] Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul 110744, South Korea

[6] CHA Univ, Dept Appl Biosci, Seoul 135081, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期

基金：

新加坡国家研究基金会;

关键词：

biocompatibility; contrast agents; coordination modes; nanoparticles; polymers; SUPERPARAMAGNETIC IRON-OXIDE; SEMICONDUCTOR QUANTUM DOTS; LYMPH-NODE METASTASES; IN-VIVO; CONTRAST AGENT; NONINVASIVE DETECTION; FE3O4; NANOPARTICLES; GOLD NANOPARTICLES; SURFACE-CHEMISTRY; STAR POLYMERS;

D O I：

10.1002/anie.201101521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful invivo MRI application using functionalized Fe 3O 4 nanoparticles confirmed their suitability for various biomedical applications. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11360 / 11365

页数：6

共 84 条

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