Severe Acute Respiratory Syndrome Coronavirus 2 Third Vaccine Immune Response in Multiple Sclerosis Patients Treated with Ocrelizumab

被引：28

作者：

Brill, Livnat ^{[1
,2
]}

Raposo, Catarina ^{[3
]}

Rechtman, Ariel ^{[1
,2
]}

Zveik, Omri ^{[1
,2
]}

Levin, Netta ^{[1
,2
]}

Oiknine-Djian, Esther ^{[4
,5
]}

Wolf, Dana G. ^{[4
,5
]}

Vaknin-Dembinsky, Adi ^{[1
,2
]}

机构：

[1] Hadassah Hebrew Univ Med Ctr, Dept Neurol, Lab Neuroimmunol, Ein Kerem POB 12000, IL-91120 Jerusalem, Israel

[2] Hadassah Hebrew Univ Med Ctr, Agnes Ginges Ctr Neurogenet, Ein Kerem POB 12000, IL-91120 Jerusalem, Israel

[3] F Hoffmann La Roche, Basel, Switzerland

[4] Hadassah Hebrew Univ Med Ctr, Clin Virol Unit, Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Lautenberg Ctr Gen & Tumor Immunol, Fac Med, Jerusalem, Israel

来源：

ANNALS OF NEUROLOGY | 2022年 / 91卷 / 06期

关键词：

D O I：

10.1002/ana.26343

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The introduction of a third-dose vaccination along with new variants of concern raises questions regarding serology and T-cell responses in patients with multiple sclerosis (pwMS) treated with B-cell depletion who develop attenuated humoral response to vaccines. The aim of this study was to longitudinally evaluate humoral and cellular response to SARS-CoV-2 mRNA vaccine in ocrelizumab-treated pwMS before and following a third vaccine dose. Following the third vaccine dose, patients who are low or nonresponders following initial vaccination did not increase antibody titers. In healthy controls and ocrelizumab-treated pwMS, cellular response decreased 6 months after initial vaccination and increased significantly after the third dose. ANN NEUROL 2022

引用

页码：796 / 800

页数：5

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