Relation of N-terminal pro-brain natriuretic peptide and new-onset atrial fibrillation in patients with acute coronary syndrome: a systematic review and meta-analysis

被引:11
作者
Gao, Xiongyi
Zeng, Ruixiang
Liao, Pengda
Zhu, Huizheng
Zhang, Minzhou [1 ,2 ]
机构
[1] Guangzhou Univ Chinese Med, Div Chest Pain Ctr, Guangdong Prov Hosp Chinese Med, Guangzhou 510120, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510120, Guangdong, Peoples R China
关键词
Acute coronary syndrome; atrial fibrillation; N-terminal pro-brain natriuretic peptide; ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; HEART-FAILURE; EPIDEMIOLOGY; INFLAMMATION; ASSOCIATION;
D O I
10.1080/00365513.2016.1199048
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Several observational studies evaluated the associations of baseline N-terminal pro-brain natriuretic peptide (NT-proBNP) and new-onset atrial fibrillation (AF) in patients with acute coronary syndrome (ACS), but the results were contradictory.Methods: Electronic bibliographic databases were searched from inception to May 2015, and the results reviewed by two independent reviewers. Pooled standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to assess associations between NT-proBNP levels and new-onset AF in patients with ACS. We performed sensitivity analyses to explore the potential sources of heterogeneity and estimated publication biases.Results: Six papers, including 5861 patients (438 with AF and 5423 without AF) with ACS were analyzed. Overall, the NT-proBNP levels were higher in patients with new-onset AF than controls without AF. The SMD of the NT-proBNP levels between the patients with and those without AF was 0.53 units (95% CI 0.37-0.70), test for overall effect z-score =6.30 (p<0.00001). The heterogeneity test showed that there were moderate differences between individual studies (p=0.02; I-2=62%). Further analysis revealed that differences of ethnic groups and the sample size of studies possibly account for this heterogeneity.Conclusions: In spite of moderate heterogeneity across the enrolled studies, our meta-analysis suggests that increased NT-proBNP levels are associated with greater risk of new-onset AF with ACS, which indicates that NT-proBNP levels may be a useful biomarker in predicting new-onset AF in patients with ACS.
引用
收藏
页码:460 / 464
页数:5
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