Study of physicochemical and biological properties of calcium phosphate coatings prepared by RF magnetron sputtering of silicon-substituted hydroxyapatite

被引：22

作者：

Pichugin, V. F. ^{[1
,2
]}

Surmeneva, M. A. ^{[1
,2
]}

Surmenev, R. A. ^{[1
,2
]}

Khlusov, I. A. ^{[1
,2
]}

Epple, M. ^{[3
]}

机构：

[1] Tomsk Polytech Univ, Biomat & Bioengn Sci & Educ Ctr, Pr Lenina 30, Tomsk 634034, Russia

[2] Siberian State Med Univ, Tomsk 634034, Russia

[3] Duisburg Essen Univ, Inst Inorgan Chem, D-45117 Essen, Germany

来源：

JOURNAL OF SURFACE INVESTIGATION | 2011年 / 5卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

NICKEL-TITANIUM; MICROSTRUCTURE; DEPOSITION; CERAMICS; CELLS;

D O I：

10.1134/S1027451011090138

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

Coatings based on pure silicon and silicon-substituted hydroxyapatite were grown by RF magnetron sputtering. The coating surface morphology, phase and elemental composition were studied by scanning electron microscopy, energy-dispersive X-ray analysis, and infrared spectroscopy. It was found that coatings are X-ray-amorphous, their elemental composition being controlled by the sputtered target composition. The distribution of elements over the coating surface is homogeneous. Medical and biological properties of coatings were studied in vivo and in vitro. Osteogenic properties of coatings were studied. Coatings grown by sputtering of a stoichiometric hydroxyapatite target are biocompatible without osteoinductive activity. The introduction of silicate ions into the hydroxyapatite structure that forms an electrode target significantly enhances the in vivo effect of CaP magnetron coatings on the osteogenic activity and stromal bone-marrow stem cells.

引用

页码：863 / 869

页数：7

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