Oxidations catalyzed by phenylacetone monooxygenase from Thermobifida fusca

被引：70
作者：
de Gonzalo, G
Pazmiño, DET
Ottolina, G
Fraaije, MW
Carrea, G
机构：
[1] CNR, Ist Chim Riconoscimento Mol, I-20131 Milan, Italy
[2] Univ Groningen, Biochem Lab, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands
来源：
TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 18期
关键词：
D O I：
10.1016/j.tetasy.2005.08.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Several organic sulfides, ketones and other organic systems have been tested as substrates in oxidation reactions catalyzed by the recently discovered phenylacetone monooxygenase from Thermobifida fusca. The biocatalytic properties of this Baeyer-Villiger monooxygenase have been studied, revealing reactivity with a large range of sulfides and ketones. Oxidations of several sulfoxides, an amine and an organoboron compound were also observed. The enzyme is able to oxidize a number of sulfides with excellent enantioselectivity, demonstrating the catalytic potential of this novel biocatalyst. (C) 2005 Elsevier Ltd. All rights reserved.
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页码：3077 / 3083
页数：7
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