MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer

被引：42

作者：

Tang, Lin ^{[1
]}

Chen, Feng ^{[2
]}

Pang, Er-Jun ^{[2
]}

Zhang, Zhi-Qi ^{[2
]}

Jin, Bing-Wei ^{[2
]}

Dong, Wei-Feng ^{[2
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Basic Med Sci, Nanjing 210023, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Div Gen Surg, Shanghai 200233, Peoples R China

来源：

ONCOLOGY REPORTS | 2015年 / 33卷 / 04期

关键词：

gastric cancer; ANUBL1; miR-182; proliferation; GENE-EXPRESSION; SEQUENCE; GROWTH; CELLS;

D O I：

10.3892/or.2015.3798

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNA-182 (miR-182) is significantly downregulated in human gastric tissue samples. Overexpression of miR-182 suppresses the proliferation and colony formation of gastric cancer cells. However, new aspects of the mechanism are still emerging in gastric cancer. ANUBL1, also known as ZFAND4 (zinc finger, AN1-type domain 4), its roles are scarely reported in cancer. In this study, we not only showed that ANUBL1 as an oncogene was upregulated and could promote proliferation of SGC-7901 cells, but also demonstrated that its overexpression led to a strong decrease of miR-182 expression and expression of ANUBL1 was in turn directly downregulated by miR-182, thereby establishing a negative feedback loop between miR-182 and ANUBL1. The elucidation of the mechanisms of miR-182 targeting ANUBL1 in gastric cancer helps us to further understand the mechanism of gastric cancer initiation and progression.

引用

页码：1707 / 1716

页数：10

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