Matrilysin is associated with progression of colorectal tumor

被引：76

作者：

Ishikawa, T

Ichikawa, Y

Mitsuhashi, M

Momiyama, N

Chishima, T

Tanaka, K

Yamaoka, H

Miyazakic, K

Nagashima, Y

Akitaya, T

Shimada, H

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PATHOL,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN

[2] HITACHI CHEM RES CTR,IRVINE,CA

[3] HITACHI CHEM CO,HITACHI,IBARAKI,JAPAN

[4] YOKOHAMA CITY UNIV,KIHARA INST BIOL RES,YOKOHAMA,KANAGAWA,JAPAN

来源：

CANCER LETTERS | 1996年 / 107卷 / 01期

关键词：

matrilysin; gelatinase-A; gelatinase-B; colorectal tumor;

D O I：

10.1016/0304-3835(96)04336-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matrilysin with lower levels than cancers. The level of matrilysin mRNA expression increased with the advancement of stages of colorectal cancers, consequently a relatively higher expression was observed in liver metastatic tumors than primary tumors. These results suggest that matrilysin mRNA expression was correlated with the progression of colorectal tumors, and this enzyme may also play a role in developing metastatic tumors in liver.

引用

页码：5 / 10

页数：6

共 20 条

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