A single-cell atlas of human and mouse white adipose tissue

被引：439

作者：

Emont, Margo P. ^{[1
,2
]}

Jacobs, Christopher ^{[1
,2
]}

Essene, Adam L. ^{[1
]}

Pant, Deepti ^{[1
]}

Tenen, Danielle ^{[1
,2
]}

Colleluori, Georgia ^{[3
]}

Di Vincenzo, Angelica ^{[3
]}

Jorgensen, Anja M. ^{[4
]}

Dashti, Hesam ^{[2
]}

Stefek, Adam ^{[2
]}

McGonagle, Elizabeth ^{[2
]}

Strobel, Sophie ^{[2
]}

Laber, Samantha ^{[2
]}

Agrawal, Saaket ^{[2
,5
]}

Westcott, Gregory P. ^{[1
]}

Kar, Amrita ^{[1
,2
]}

Veregge, Molly L. ^{[1
]}

Gulko, Anton ^{[1
]}

Srinivasan, Harini ^{[1
,2
]}

Kramer, Zachary ^{[1
]}

De Filippis, Eleanna ^{[6
]}

Merkel, Erin ^{[1
]}

Ducie, Jennifer ^{[7
]}

Boyd, Christopher G. ^{[8
]}

Gourash, William ^{[9
]}

Courcoulas, Anita ^{[9
]}

Lin, Samuel J. ^{[10
]}

Lee, Bernard T. ^{[10
]}

Morris, Donald ^{[10
]}

Tobias, Adam ^{[10
]}

Khera, Amit, V ^{[2
,5
,11
]}

Claussnitzer, Melina ^{[2
,12
,13
]}

Pers, Tune H. ^{[4
]}

Giordano, Antonio ^{[3
]}

Ashenberg, Orr ^{[14
]}

Regev, Aviv ^{[14
,15
,16
]}

Tsai, Linus T. ^{[1
,2
,11
]}

Rosen, Evan D. ^{[1
,2
,11
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[3] Marche Polytech Univ, Ctr Obes, Dept Expt & Clin Med, Ancona, Italy

[4] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[5] Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA 02114 USA

[6] Mayo Clin Scottsdale, Div Endocrinol Diabet & Metab, Scottsdale, AZ USA

[7] Beth Israel Deaconess Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Boston, MA 02215 USA

[8] Beth Israel Deaconess Med Ctr, Dept Surg, 330 Brookline Ave, Boston, MA 02215 USA

[9] Univ Pittsburgh, Ctr Hlth, Dept Surg, Pittsburgh, PA USA

[10] Beth Israel Deaconess Med Ctr, Dept Surg, Div Plast Surg, 330 Brookline Ave, Boston, MA 02215 USA

[11] Harvard Med Sch, Boston, MA 02115 USA

[12] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[13] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA

[14] Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA

[15] MIT, Dept Biol, Koch Inst Integrat Canc Res, Howard Hughes Med Inst,Koch Inst Integrat Canc Re, Cambridge, MA USA

[16] Genentech Inc, San Francisco, CA 94080 USA

来源：

NATURE | 2022年 / 603卷 / 7903期

关键词：

GENOME-WIDE ASSOCIATION; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; GENETIC-LOCI; CROSS-TALK; SENSITIVITY; HOMEOSTASIS; GLUCOSE; IMPACT;

D O I：

10.1038/s41586-022-04518-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence(1). High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition(1), and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes(2). Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

引用

页码：926 / +

页数：32

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