Copper-Catalyzed Direct Oxidative C-H Amination of Benzoxazoles with Formamides or Secondary Amines under Mild Conditions

被引：139

作者：

Li, Yaming ^{[1
]}

Xie, Yusheng ^{[1
]}

Zhang, Rong ^{[1
]}

Jin, Kun ^{[1
]}

Wang, Xiuna ^{[1
]}

Duan, Chunying ^{[1
]}

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Sch Chem Engn, Dalian 116024, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 13期

基金：

中国国家自然科学基金;

关键词：

COUPLING REACTION; FUNCTIONALIZATION; AZOLES; BONDS; ACIDS; ACTIVATION; REACTIVITY; DIOXYGEN;

D O I：

10.1021/jo200447x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile, efficient, and practical method for copper-catalyzed direct C-H amination of benzoxazoles with formamides or secondary amines has been developed. The system can be performed in the absence of external base and only requires O-2 or even air as oxidant. A variety of substituted benzoxazol-2-amines were synthesized with moderate to excellent yield.

引用

页码：5444 / 5449

页数：6

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